Michael Giacomelli, Duke University

Angle Resolved Low Coherence Interferometry (a/LCI) is a light scattering technology that combines Fourier domain interferometric detection with computational light scattering models to measure the geometry and organization of cellular scatterers. In the a/LCI technique, high-speed interferometric acquisition is coupled to a database look up of pre-computed light scattering solutions. A database search is then used to invert the light scattering measurements revealing cellular geometry and organization. The scientific and clinical usefulness of the technique therefore depends on processing Fourier domain axial scans and comparing them to a database of known scatterers, as well as assembling large databases of light scattering solutions using distributed computing. In this talk, a brief overview of the a/LCI technique, experiments and clinical trials is presented, as well as the tools and techniques used to overcome computational challenges.